AKA penicillin G
Septicemia in children
The enzymes that hydrolyze the peptidoglycan cross-links continue to function, which weakens the cell wall of the bacterium
In addition, the build-up of peptidoglycan precursors triggers the activation of bacterial cell wall hydrolases and autolysins, which further digest the bacteria's existing peptidoglycan
Shows a synergistic effect with aminoglycosides
inhibition of peptidoglycan synthesis allows aminoglycosides to penetrate the bacterial cell wall more easily, allowing its disruption of bacterial protein synthesis within the cell
This results in a lowered MBC for susceptible organisms.