Benzylpenicillin

AKA penicillin G

Indications

• Cellulitis

  • Bacterial endocarditis

• Gonorrhea

• Meningitis

  • Aspiration pneumonia, lung abscess

  • Community-acquired pneumonia

• Syphilis

  • Septicemia in children

• Septic Arthritis

Administration/Absorption

• parenteral

Dosage

Distribution

Mechanism

• • Inhibits the formation of peptidoglycan cross-links in the bacterial cell wall

    • The β-lactam moiety (functional group) of penicillin binds to the enzyme (DD-transpeptidase) that links the peptidoglycan molecules in bacteria.

    • The enzymes that hydrolyze the peptidoglycan cross-links continue to function, which weakens the cell wall of the bacterium

    • In addition, the build-up of peptidoglycan precursors triggers the activation of bacterial cell wall hydrolases and autolysins, which further digest the bacteria's existing peptidoglycan

  • Shows a synergistic effect with aminoglycosides

    • inhibition of peptidoglycan synthesis allows aminoglycosides to penetrate the bacterial cell wall more easily, allowing its disruption of bacterial protein synthesis within the cell

    • This results in a lowered MBC for susceptible organisms.

Excretion

Side effects

Interactions

Contraindications