nausea and vomiting
facilitate gastric emptying in patients with gastroparesis
binds to dopamine D2 receptors where it is a receptor antagonist, and is also a mixed 5-HT3 receptor antagonist/5-HT4 receptor agonist.
anti-emetic action of metoclopramide is due to its antagonist activity at D2 receptors in the chemoreceptor trigger zone (CTZ) in the central nervous system (CNS)
this action prevents nausea and vomiting triggered by most stimuli.
At higher doses, 5-HT3 antagonist activity may also contribute to the anti-emetic effect.
The prokinetic activity of metoclopramide is mediated by muscarinic activity, D2 receptor antagonist activity and 5-HT4 receptor agonist activity.
The prokinetic effect itself may also contribute to the anti-emetic effect.