High blood pressure (HBP) or hypertension (HTN)
relatively safe in pregnancy:
variable absorption from the gastrointestinal tract.
Competitive inhibitor of the DOPA decarboxylase, which converts L-DOPA into dopamine
Dopamine is a precursor for norepinephrine (noradrenaline) and subsequently epinephrine (adrenaline).
Inhibition results in reduced dopaminergic and adrenergic neurotransmission in the peripheral nervous system.
This effect may lower blood pressure and cause central nervous system effects such as depression, anxiety, apathy, anhedonia, and parkinsonism.
α-methylnorepinephrine is an agonist of presynaptic central nervous system α2-adrenergic receptors
Activation of these receptors in the brainstem appears to inhibit sympathetic nervous system output and lower blood pressure.
metabolized in the liver and intestines
Converted to α-methylnorepinephrine by dopamine beta-hydroxylase (DBH)