Salmeterol

Indications

• • asthma

• COPD

Administration/Absorption

• • proprietary "disk-styled" inhaler that releases a powdered form

  • prescribed concurrently with a corticosteroid, such as beclomethasone

Distribution

Mechanism

• • long-acting beta-adrenoceptor agonist (LABA)

    • chain length of 11-atoms from the amine

    • bulkiness makes the compound more lipophilic and it also makes it β receptor selective

  • long duration of formoterol action occurs by the formoterol molecules initially diffusing into the plasma membrane of the lung cells

    • then slowly being released back outside the cell where they can come into contact with the beta-2 adrenoceptors

Excretion

Side effects