Salmeterol

Indications

Administration/Absorption

    • proprietary "disk-styled" inhaler that releases a powdered form

    • prescribed concurrently with a corticosteroid, such as beclomethasone

Distribution

Mechanism

    • long-acting beta-adrenoceptor agonist (LABA)

      • chain length of 11-atoms from the amine

      • bulkiness makes the compound more lipophilic and it also makes it β receptor selective

    • long duration of formoterol action occurs by the formoterol molecules initially diffusing into the plasma membrane of the lung cells

      • then slowly being released back outside the cell where they can come into contact with the beta-2 adrenoceptors

Excretion

Side effects